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Nicholas R Casewell Selected Research

Snake Bites (Snake Bite)

6/2022In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus.
6/2022Correction: Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms.
1/2022Profiling the Murine Acute Phase and Inflammatory Responses to African Snake Venom: An Approach to Inform Acute Snakebite Pathology.
1/2022TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming phase 1 (safety, tolerability, pharmacokinetics and pharmacodynamics in healthy Kenyan adults).
1/2022Virus-like particles displaying conserved toxin epitopes stimulate polyspecific, murine antibody responses capable of snake venom recognition.
12/2021A Genus-Wide Bioactivity Analysis of Daboia (Viperinae: Viperidae) Viper Venoms Reveals Widespread Variation in Haemotoxic Properties.
6/2021Erythrocyte haemotoxicity profiling of snake venom toxins after nanofractionation.
1/2021The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming.
1/2021Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms.
1/2021Biogeographical venom variation in the Indian spectacled cobra (Naja naja) underscores the pressing need for pan-India efficacious snakebite therapy.
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Nicholas R Casewell Research Topics

Disease

41Snake Bites (Snake Bite)
06/2022 - 11/2009
5Bites and Stings (Sting)
01/2021 - 03/2015
4Disseminated Intravascular Coagulation
06/2022 - 04/2017
3Neoplasms (Cancer)
06/2021 - 09/2013
3Neglected Diseases
01/2020 - 08/2011
2Hemolysis
01/2022 - 06/2020
2Edema (Dropsy)
09/2020 - 04/2020
2Adenocarcinoma of Lung
06/2020 - 09/2013
2Necrosis
04/2020 - 09/2013
2Hemorrhage
04/2020 - 09/2013
1Leukocytosis (Pleocytosis)
01/2022
1Heavy Metal Poisoning
01/2022
1Lymphopenia (Lymphocytopenia)
01/2022
1Melanoma (Melanoma, Malignant)
06/2021
1Acquired Immunodeficiency Syndrome (AIDS)
10/2020
1Type 2 Diabetes Mellitus (MODY)
06/2020
1Adenocarcinoma
06/2020
1Pain (Aches)
04/2020
1Paralysis (Palsy)
01/2019
1Glioma (Gliomas)
06/2015

Drug/Important Bio-Agent (IBA)

31Antivenins (Antivenoms)IBA
06/2022 - 11/2009
28VenomsIBA
06/2022 - 11/2009
15Snake Venoms (Snake Venom)IBA
06/2022 - 01/2014
6Pharmaceutical PreparationsIBA
06/2021 - 01/2017
5Proteins (Proteins, Gene)FDA Link
06/2020 - 09/2013
3Unithiol (DMPS)IBA
06/2022 - 01/2020
3AntibodiesIBA
12/2020 - 01/2014
2marimastatIBA
06/2022 - 08/2020
2Metalloproteases (Metalloproteinases)IBA
06/2022 - 09/2018
2Fibrinogen (Factor I)FDA Link
06/2022 - 09/2018
2Chelating AgentsIBA
01/2022 - 01/2020
2NeurotoxinsIBA
01/2021 - 01/2019
2varespladibIBA
08/2020 - 06/2020
2EnzymesIBA
06/2020 - 01/2018
2Phospholipases A2 (Phospholipase A2)IBA
06/2020 - 06/2020
2Protein Isoforms (Isoforms)IBA
06/2020 - 01/2020
2Peptides (Polypeptides)IBA
06/2020 - 03/2015
1Prothrombin (Factor II)IBA
06/2022
1Blood Coagulation Factors (Coagulation Factor)IBA
06/2022
1Interleukin-6 (Interleukin 6)IBA
01/2022
1Cytotoxins (Cytolysins)IBA
06/2021
1Viper Venoms (Viper Venom)IBA
06/2021
1Biological ProductsIBA
01/2021
1Complement System Proteins (Complement)IBA
01/2021
1Glucose (Dextrose)FDA LinkGeneric
06/2020
1Insulin (Novolin)FDA Link
06/2020
1Peptide Hydrolases (Proteases)FDA Link
04/2020
1Monoclonal AntibodiesIBA
01/2020
1MetalsIBA
01/2020
1Immunoglobulins (Immunoglobulin)IBA
01/2020
1Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA
01/2019
1Three Finger ToxinsIBA
01/2019
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
06/2015
1SolutionsIBA
08/2011

Therapy/Procedure

22Therapeutics
06/2022 - 11/2009
1Intravenous Administration
12/2020
1Complementary Therapies (Alternative Medicine)
01/2018